France midfielder Kante took tentative steps forward last week after self-isolation for testing positive for Covid-19.
But the 30-year-old returned to full Chelsea training on Tuesday, in another fillip for the Premier League leaders.
England full-back James missed the international fixtures due to an ankle problem but has also shaken off his injury to return to action at the Blues’ Cobham training base.
“Two key players have returned to Chelsea training to provide Thomas Tuchel with a welcome boost ahead of Saturday’s trip to Brentford,” read a Chelsea statement.
“Midfielder N’Golo Kante has returned to full training at Cobham following his period of self-isolation, whilst Reece James was also involved after withdrawing from the England squad last week due to an ankle injury picked up in the game against Manchester City.”
World Cup winner Kante will bolster Chelsea’s ranks for the trip to take on Thomas Frank’s Bees, with the former Leicester star now in line to feature in defensive midfield.
James’ availability will add options at either right centre-back or right wing-back for boss Tuchel, although Chelsea will be left to wait on injury concerns to other players.
Christian Pulisic continues to battle ankle trouble, while Romelu Lukaku suffered with muscle soreness on Belgium duty.
Meanwhile, Glen Johnson claims Chelsea would consider re-signing Tammy Abraham, who left to join Roma this summer.
Johnson said: “He’s scoring goals, enjoying his football again and he’s got a lot to offer. And naturally all the big teams are going to want strikers who are scoring goals.
“Chelsea have shown in the past that they’re not embarrassed to sign somebody back for a lot more money than they sold them for. If he continues to score goals then I think yeah they would be interested. Strikers are hard to come by, aren’t they?
“As a young Englishman, we’re all brought up to want to play in the Premier League, so I’m sure he’ll want to come back one day to settle some scores.”
“I can also see him being part of the England set-up at Qatar 2022. He’s got age on his side. He’s a big physical lad, and for me he’s decent in front of goal as well. If he continues to score goals then he’s going to be hard to look past isn’t he?”